LncHOXA10 drives liver TICs self-renewal and tumorigenesis via HOXA10 transcription activation.

ABSTRACT:

Background

Liver cancer is one of the most deadly cancers in the world. There are various cells in liver tumor bulk, including liver tumor initiating cells (TICs), which account for liver tumorigenesis, drug resistance, relapse and metastasis. The homeobox (HOX) transcription factors play critical roles in many physiological and pathological processes, while, their roles in liver TICs and liver tumorigenesis remain unknown.

Methods

An unbiased screening was performed using online-available datasets. Liver TICs were sorted by FACS using surface markers CD133, CD13 and EPCAM, or enriched by oncosphere formation assay. TIC self-renewal was examined by oncosphere formation and tumor initiation assay. Loss of function and gain of function assays were performed to examine the role

SUBMITTER: Shao M 

PROVIDER: S-EPMC6293550 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature