ErbB2-driven downregulation of the transcription factor Irf6 in breast epithelial cells is required for their 3D growth.

ABSTRACT:

Background

The ability of solid tumor cells to resist anoikis, apoptosis triggered by cell detachment from the extracellular matrix (ECM), is thought to be critical for 3D tumor growth. ErbB2/Her2 oncoprotein is often overproduced by breast tumor cells and blocks their anoikis by partially understood mechanisms. In our effort to understand them better, we observed that detachment of nonmalignant human breast epithelial cells from the ECM upregulates the transcription factor Irf6. Irf6 is thought to play an important role in mammary gland homeostasis and causes apoptosis by unknown mechanisms. We noticed that ErbB2, when overproduced by detached breast epithelial cells, downregulates Irf6.

Methods

To test whether ErbB2 downregulates Irf6 in human ErbB2-positive breast cancer

SUBMITTER: Khan IA 

PROVIDER: S-EPMC6293553 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature