When pitch adds to volume: coregulation of transcript diversity predicts gene function.

ABSTRACT:

Background

Genes corregulate their overall transcript volumes to perform their physiological functions. However, it is unknown if they additionally coregulate their transcript diversities. We studied the reliability, consistency and functional associations of co-splicing correlations of genes of interest, across two independent studies, multiple tissues and two statistical methods. We thoroughly investigated the reproducibility of co-splicing correlations of APP, the candidate gene of Azheimer's disease (AD). We then studied how co-splicing correlations in different tissues contributed to predict functional interactions of three other genes and finally computed co-splicing frequency for 17 thousand genes across 52 human tissues.

Results

We replicated co-splicing correlations

SUBMITTER: Caceres A 

PROVIDER: S-EPMC6293560 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature