Machine learning selected smoking-associated DNA methylation signatures that predict HIV prognosis and mortality.

ABSTRACT:

Background

The effects of tobacco smoking on epigenome-wide methylation signatures in white blood cells (WBCs) collected from persons living with HIV may have important implications for their immune-related outcomes, including frailty and mortality. The application of a machine learning approach to the analysis of CpG methylation in the epigenome enables the selection of phenotypically relevant features from high-dimensional data. Using this approach, we now report that a set of smoking-associated DNA-methylated CpGs predicts HIV prognosis and mortality in an HIV-positive veteran population.

Results

We first identified 137 epigenome-wide significant CpGs for smoking in WBCs from 1137 HIV-positive individuals (p < 1.70E-07). To examine whether smoking-associated CpGs were pre

SUBMITTER: Zhang X 

PROVIDER: S-EPMC6293604 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature