Transcriptome profile in bursa of Fabricius reveals potential mode for stress-influenced immune function in chicken stress model.

ABSTRACT:

Background

The molecular mechanisms underlying stress-influenced immune function of chicken (Gallus Gallus) are not clear. The stress models can be established effectively by feeding chickens corticosterone (CORT) hormone. The bursa of Fabricius is a unique central immune organ of birds. RNA-Seq technology was used to investigate differences in the expression profiles of immune-related genes and associated pathways in the bursa of Fabricius to clarify molecular mechanisms. The aim of this study was to broaden the understanding of the stress-influenced immune function in chickens.

Results

Differentially expressed genes (DEGs) in the bursa of Fabricius between experimental group (basal diet with added CORT 30 mg/kg; C_B group) and control group (basal diet; B_B group) were ide

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC6293626 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature