The changing landscape of phase II/III metastatic sarcoma clinical trials-analysis of ClinicalTrials.gov.

ABSTRACT:

Background

Well-designed clinical trials are of great importance in validating novel treatments and ensuring an evidence-based approach for sarcoma. This study aimed to provide a comprehensive landscape of the characteristics of metastatic or advanced sarcoma clinical trials using the substantial resource of the ClincialTrials.gov database.

Methods

We identified 260,755 trials registered with ClinicalTrials.gov in the last 20 years, and 277 of them were eligible for inclusion. The baseline characteristics were ascertained for each trial. The trials were systematically reviewed to validate their classification into 96 trials registered before 2008 and 181 trials registered between 2008 and 2017.

Results

We found that in the last decade, metastatic and advanced sarcoma

SUBMITTER: Que Y 

PROVIDER: S-EPMC6293634 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature