Monocyte-derived macrophages expand the murine stress erythropoietic niche during the recovery from anemia.

ABSTRACT: Anemic stress induces a physiological response that includes the rapid production of new erythrocytes. This process is referred to as stress erythropoiesis. It is best understood in the mouse where it is extramedullary and utilizes signals and progenitor cells that are distinct from bone marrow steady-state erythropoiesis. The development of stress erythroid progenitors occurs in close association with the splenic stress erythropoiesis niche. In particular, macrophages in the niche are required for proper stress erythropoiesis. Here we show that the expansion of the niche occurs in concert with the proliferation and differentiation of stress erythroid progenitors. Using lineage tracing analysis in 2 models of anemic stress, we show that the expansion of the splenic niche is due to the recr

SUBMITTER: Liao C 

PROVIDER: S-EPMC6293871 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature