A synthesis approach of mouse studies to identify genes and proteins in arterial thrombosis and bleeding.

ABSTRACT: Antithrombotic therapies reduce cardiovascular diseases by preventing arterial thrombosis and thromboembolism, but at expense of increased bleeding risks. Arterial thrombosis studies using genetically modified mice have been invaluable for identification of new molecular targets. Because of low sample sizes and heterogeneity in approaches or methodologies, a formal meta-analysis to compare studies of mice with single-gene defects encountered major limitations. To overcome these, we developed a novel synthesis approach to quantitatively scale 1514 published studies of arterial thrombus formation (in vivo and in vitro), thromboembolism, and tail-bleeding of genetically modified mice. Using a newly defined consistency parameter (CP), indicating the strength of published data, comparisons were

SUBMITTER: Baaten CCFMJ 

PROVIDER: S-EPMC6293874 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature