Effect and cost-effectiveness of pneumococcal conjugate vaccination: a global modelling analysis.

ABSTRACT:

Background

Introduction of pneumococcal conjugate vaccines (PCVs) has substantially reduced disease burden due to Streptococcus pneumoniae, a leading cause of childhood morbidity and mortality globally. However, PCVs are among the most expensive vaccines, hindering their introduction in some settings and threatening sustainability in others. We aimed to assess the effect and cost-effectiveness of introduction of 13-valent PCV (PCV13) vaccination globally.

Methods

We assessed the incremental cost-effectiveness ratio of PCV13 introduction by integrating two models: an ecological model (a parsimonious, mechanistic model validated with data from post-seven-valent PCV introduction in 13 high-income settings) to predict the effect of PCV on childhood invasive pneumococcal disease,

SUBMITTER: Chen C 

PROVIDER: S-EPMC6293964 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature