BDNF genotype and tDCS interaction in aphasia treatment.

ABSTRACT:

Background

Several studies, including a randomized controlled trial by our group, support applying anodal tDCS (A-tDCS) to the left hemisphere during behavioral aphasia treatment to improve outcomes. A clear mechanism explaining A-tDCS's efficacy has not been established, but modulation of neuroplasticity may be involved.

Objective/hypothesis

The brain-derived neurotrophic factor (BDNF) gene influences neuroplasticity and may modulate the effects of tDCS. Utilizing data from our recently completed trial, we conducted a planned test of whether aphasia treatment outcome is influenced by interaction between A-tDCS and a single-nucleotide polymorphism of the BDNF gene, rs6265.

Methods

Seventy-four individuals with chronic stroke-induced aphasia completed 15 language thera

SUBMITTER: Fridriksson J 

PROVIDER: S-EPMC6293970 | biostudies-literature | 2018 Nov - Dec

REPOSITORIES: biostudies-literature