Ontology highlight
ABSTRACT:
SUBMITTER: Chen S
PROVIDER: S-EPMC6294005 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Nature communications 20181213 1
To balance immunity and tolerance, the endogenous pool of Foxp3<sup>+</sup> regulatory T (T<sub>reg</sub>) cells is tightly controlled, but the underlying mechanisms of this control remain poorly understood. Here we show that the number of T<sub>reg</sub> cells is negatively regulated by the kinase Lkb1 in dendritic cells (DCs). Conditional knockout of the Lkb1 gene in DCs leads to excessive T<sub>reg</sub> cell expansion in multiple organs and dampens antigen-specific T cell immunity. Lkb1-defi ...[more]