Personal Mutanomes Meet Modern Oncology Drug Discovery and Precision Health.

ABSTRACT: Recent remarkable advances in genome sequencing have enabled detailed maps of identified and interpreted genomic variation, dubbed "mutanomes." The availability of thousands of exome/genome sequencing data has prompted the emergence of new challenges in the identification of novel druggable targets and therapeutic strategies. Typically, mutanomes are viewed as one- or two-dimensional. The three-dimensional protein structural view of personal mutanomes sheds light on the functional consequences of clinically actionable mutations revealed in tumor diagnosis and followed up in personalized treatments, in a mutanome-informed manner. In this review, we describe the protein structural landscape of personal mutanomes and provide expert opinions on rational strategies for more streamlined oncologi

SUBMITTER: Cheng F 

PROVIDER: S-EPMC6294046 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature