Click chemistry enables quantitative chiroptical sensing of chiral compounds in protic media and complex mixtures.

ABSTRACT: Click reactions have become powerful synthetic tools with unique applications in the health and materials sciences. Despite the progress with optical sensors that exploit the principles of dynamic covalent chemistry, metal coordination or supramolecular assemblies, quantitative analysis of complex mixtures remains challenging. Herein, we report the use of a readily available coumarin conjugate acceptor for chiroptical click chirality sensing of the absolute configuration, concentration and enantiomeric excess of several compound classes. This method has several attractive features, including wide scope, fast substrate fixation without by-product formation or complicate equilibria often encountered in reversible substrate binding, excellent solvent compatibility, and tolerance of air and wa

SUBMITTER: Thanzeel FY 

PROVIDER: S-EPMC6294054 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature