Drug delivery to atherosclerotic plaques using superparamagnetic iron oxide nanoparticles.

ABSTRACT:

Introduction

Magnetic drug targeting utilizes superparamagnetic iron oxide nanoparticles (SPIONs) to accumulate drugs in specified vasculature regions.

Methods

We produced SPIONs conjugated with dexamethasone phosphate (SPION-DEXA). The efficacy of magnetic drug targeting was investigated in a rabbit model of atherosclerosis induced by balloon injury and high cholesterol diet.

Results

In vitro, SPION-DEXA were well-tolerated by endothelial cells. SPION-DEXA were internalized by human peripheral blood mononuclear cells and induced CD163 expression comparable with the free drug. In vivo, magnetic targeting of SPIONs to abdominal aorta was confirmed by histology. Upon vascular injury followed by high-cholesterol diet, early administration of SPION-DEXA enhanced the infla

SUBMITTER: Matuszak J 

PROVIDER: S-EPMC6294059 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature