Excitable Adult-Generated GABAergic Neurons Acquire Functional Innervation in the Cortex after Stroke.

ABSTRACT: Ischemic stroke enhances the proliferation of adult-generated precursor cells that ectopically migrate toward the infarct. Studies have correlated precursor cell proliferation and subsequent adult neurogenesis with enhanced stroke recovery, yet it remains unclear whether stroke can generate new neurons capable of functional integration into the injured cortex. Here, using single and bitransgenic reporter mice, we identify spatial and temporal features of a multilineage cellular response to focal ischemia. We reveal that a small population of stroke-induced immature neurons accumulate within the peri-infarct region of the adult sensorimotor cortex, exhibit voltage-dependent conductances, fire action potentials, express GABAergic markers, and receive sparse GABAergic synaptic inputs. Collect

SUBMITTER: Kannangara TS 

PROVIDER: S-EPMC6294071 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature