Association between MTHFR 677C>T Polymorphism and Vitamin B12 Deficiency: A Case-control Study.

ABSTRACT:

Background

Vitamin B12 (cobalamin) deficiency is a prevalent worldwide health concern. Several factors are associated with vitamin B12 deficiency including lifestyle, genetic predisposition, and malfunctions in the absorption and transport of vitamin B12. In the current case-control study, we aimed at investigating the association between MTHFR polymorphisms and vitamin B12 deficiency in a Jordanian population.

Methods

Two polymorphic sites of the MTHFR gene (c.677C>T, rs1801133 and c.1286A>C, rs1801131) were analyzed using RFLP and DNA sequencing in a group of vitamin B12 deficient individuals (45 males and 55 females). As a control, 100 matching individuals (age and sex) with vitamin B12 levels > 200 ng/mL were also recruited for this study.

Results

The MTHFR c.677C

SUBMITTER: Al-Batayneh KM 

PROVIDER: S-EPMC6294092 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature