Myo-inositol Oxygenase as a Novel Marker in the Diagnosis of Acute Kidney Injury.

ABSTRACT:

Background

Due to the lack of diagnostic efficiency of serum creatinine in acute kidney injury (AKI), there is a pressing need to develop novel diagnostic markers. Therefore, in this study, we evaluated myo-inositol oxygenase (MIOX), neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C in terms of their applicability in the diagnosis of AKI.

Methods

We enrolled a total of 39 AKI patients and 38 healthy controls in the study. We compared the levels of serum MIOX, NGAL and cystatin C between the two groups.

Results

We found that the concentrations of serum creatinine, blood-urea nitrogen, MIOX and cystatin C were higher in the AKI group. According to the receiver operating characteristic analysis, the area under the curve (AUC) values were 0.694 (95% CI 0.57

SUBMITTER: Mertoglu C 

PROVIDER: S-EPMC6294104 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature