Leukocyte-Derived Interleukin-10 Aggravates Postoperative Ileus.

ABSTRACT: Objective: Postoperative ileus (POI) is an inflammation-mediated complication of abdominal surgery, characterized by intestinal dysmotility and leukocyte infiltration into the muscularis externa (ME). Previous studies indicated that interleukin (IL)-10 is crucial for the resolution of a variety of inflammation-driven diseases. Herein, we investigated how IL-10 affects the postoperative ME inflammation and found an unforeseen role of IL-10 in POI. Design: POI was induced by a standardized intestinal manipulation (IM) in C57BL/6 and multiple transgenic mouse strain including C-C motif chemokine receptor 2^-/-, IL-10^-/-, and LysM^cre/IL-10^fl/fl mice. Leukocyte infiltration, gene and protein expression of cytokines, chemokines, and macrop

SUBMITTER: Stein K 

PROVIDER: S-EPMC6294129 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature