Fast skeletal troponin I, but not the slow isoform, is increased in patients under statin therapy: a pilot study.

ABSTRACT:

Introduction

Statin therapy is often associated with muscle complaints and increased serum creatine kinase (CK). However, although essential in determining muscle damage, this marker is not specific for skeletal muscle. Recent studies on animal models have shown that slow and fast isoforms of skeletal troponin I (ssTnI and fsTnI, respectively) can be useful markers of skeletal muscle injury. The aim of this study was to evaluate the utility of ssTnI and fsTnI as markers to monitor the statin-induced skeletal muscle damage.

Materials and methods

A total of 51 patients (14 using and 37 not using statins) admitted to the intensive care unit of the University of Ferrara Academic Hospital were included in this observational study. Serum activities of CK, aldolase, alanine aminotr

SUBMITTER: Trentini A 

PROVIDER: S-EPMC6294157 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature