Polyoxometalates: more than a phasing tool in protein crystallography.

ABSTRACT: Protein crystallography is the most widely used method for determining the molecular structure of proteins and obtaining structural information on protein-ligand complexes at the atomic level. As the structure determines the functions and properties of a protein, crystallography is of immense importance for nearly all research fields related to biochemistry. However, protein crystallography suffers from some major drawbacks, whereby the unpredictability of the crystallization process represents the main bottleneck. Crystallization is still more or less a 'trial and error' based procedure, and therefore, very time and resource consuming. Many strategies  have been developed in the past decades to improve or enable the crystallization of proteins, whereby the use of so-called additives, whic

SUBMITTER: Bijelic A 

PROVIDER: S-EPMC6294228 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature