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When LMO1 Meets MYCN, Neuroblastoma Is Metastatic.

ABSTRACT: LMO1 is a high-risk neuroblastoma susceptibility gene, but how LMO1 cooperates with MYCN in neuroblastoma tumorigenesis is unclear. In this issue of Cancer Cell, Zhu et al. develop a novel zebrafish model that elucidates a mechanism by which LMO1 and MYCN synergistically initiate neuroblastoma and contribute to metastatic disease progression.

SUBMITTER: Liu Z 

PROVIDER: S-EPMC6294297 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature

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When LMO1 Meets MYCN, Neuroblastoma Is Metastatic.

Liu Zhihui Z   Thiele Carol J CJ  

Cancer cell 20170901 3

LMO1 is a high-risk neuroblastoma susceptibility gene, but how LMO1 cooperates with MYCN in neuroblastoma tumorigenesis is unclear. In this issue of Cancer Cell, Zhu et al. develop a novel zebrafish model that elucidates a mechanism by which LMO1 and MYCN synergistically initiate neuroblastoma and contribute to metastatic disease progression. ...[more]

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