Polybrominated diphenyl ethers and incident pregnancy loss: The LIFE Study.

ABSTRACT:

Background

Polybrominated diphenyl ethers (PBDEs) have not been studied in relation to incident pregnancy loss in human populations, despite their ubiquitous exposure and purported reproductive toxicity.

Objectives

To investigate the association between preconception serum PBDE concentrations and incident pregnancy loss.

Methods

A preconception cohort of 501 couples was followed while trying to become pregnant, and for whom serum concentrations of 10 PBDE congeners were measured using gas chromatography-high resolution mass spectrometry. Pregnancy was prospectively identified as a positive home pregnancy test on the day of expected menstruation. Incident pregnancy loss was defined for 344 singleton pregnancies as a conversion to a negative home pregnancy test, menses,

SUBMITTER: Choi G 

PROVIDER: S-EPMC6294303 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature