Infant diet and maternal gestational weight gain predict early metabolic maturation of gut microbiomes.

ABSTRACT: Commensal gut bacterial communities (microbiomes) are predicted to influence human health and disease^1,2. Neonatal gut microbiomes are colonized with maternal and environmental flora and mature toward a stable composition over 2-3 years^3,4. To study pre- and postnatal determinants of infant microbiome development, we analyzed 402 fecal metagenomes from 60 infants aged 0-8 months, using longitudinal generalized linear mixed models (GLMMs). Distinct microbiome signatures correlated with breastfeeding, formula ingredients, and maternal gestational weight gain (GWG). Amino acid synthesis pathway accretion in breastfed microbiomes complemented normative breastmilk composition. Prebiotic oligosaccharides, designed to promote breastfed-like microflora⁵, predicted

SUBMITTER: Baumann-Dudenhoeffer AM 

PROVIDER: S-EPMC6294307 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature