Urine biomarkers of chronic kidney damage and renal functional decline in childhood-onset systemic lupus erythematosus.

ABSTRACT:

Objectives

To delineate urine biomarkers that reflect kidney structural damage and predict renal functional decline in pediatric lupus nephritis (LN).

Methods

In this prospective study, we evaluated kidney biopsies and urine samples of 89 patients with pediatric LN. Urinary levels of 10 biomarkers [adiponectin, ceruloplasmin, kidney injury molecule-1, monocyte chemotactic protein-1, neutrophil gelatinase-associated lipocalin, osteopontin, transforming growth factor-ß (TGFß), vitamin-D binding protein, liver fatty acid binding protein (LFABP), and transferrin] were measured. Regression analysis was used to identify individual and combinations of biomarkers that determine LN damage status [NIH-chronicity index (NIH-CI) score ≤ 1 vs. ≥ 2] both individually and in combination, a

SUBMITTER: Brunner HI 

PROVIDER: S-EPMC6294330 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature