Cortical Phase-Amplitude Coupling in a Progressive Model of Parkinsonism in Nonhuman Primates.

ABSTRACT: Parkinson's disease is associated with abnormal oscillatory electrical activities of neurons and neuronal ensembles throughout the basal ganglia-thalamocortical network. It has recently been documented in patients with advanced parkinsonism that the amplitude of gamma-band oscillations (50-200 Hz) in electrocorticogram recordings from the primary motor cortex is abnormally coupled to the phase of beta band oscillations within the same signals. It is not known when in the course of the disease the abnormal phase-amplitude coupling (PAC) arises, and whether it is influenced by arousal or prior exposure to dopaminergic medications. To address these issues, we analyzed the relationship between the severity of parkinsonian motor signs and the extent of PAC in a progressive model of parkinsonism

SUBMITTER: Devergnas A 

PROVIDER: S-EPMC6294400 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature