Dopamine Signaling Modulates the Stability and Integration of Intrinsic Brain Networks.

ABSTRACT: Dopaminergic projections are hypothesized to stabilize neural signaling and neural representations, but how they shape regional information processing and large-scale network interactions remains unclear. Here we investigated effects of lowered dopamine levels on within-region temporal signal variability (measured by sample entropy) and between-region functional connectivity (measured by pairwise temporal correlations) in the healthy brain at rest. The acute phenylalanine and tyrosine depletion (APTD) method was used to decrease dopamine synthesis in 51 healthy participants who underwent resting-state functional MRI (fMRI) scanning. Functional connectivity and regional signal variability were estimated for each participant. Multivariate partial least squares (PLS) analysis was used to stat

SUBMITTER: Shafiei G 

PROVIDER: S-EPMC6294404 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature