Donor biomarkers as predictors of organ use and recipient survival after neurologically deceased donor organ transplantation.

ABSTRACT:

Purpose

We sought to build prediction models for organ transplantation and recipient survival using both biomarkers and clinical information.

Materials and methods

We abstracted clinical variables from a previous randomized trial (n = 556) of donor management. In a subset of donors (n = 97), we measured two candidate biomarkers in plasma at enrollment and just prior to explantation.

Results

Secretory leukocyte protease inhibitor (SLPI) was significant for predicting liver transplantation (C-statistic 0.65 (0.53, 0.78)). SLPI also significantly improved the predictive performance of a clinical model for liver transplantation (integrated discrimination improvement (IDI): 0.090 (0.009, 0.210)). For other organs, clinical variables alone had strong predictive ability (C-s

SUBMITTER: Li S 

PROVIDER: S-EPMC6294437 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature