Bayesian inference of ancestral dates on bacterial phylogenetic trees.

ABSTRACT: The sequencing and comparative analysis of a collection of bacterial genomes from a single species or lineage of interest can lead to key insights into its evolution, ecology or epidemiology. The tool of choice for such a study is often to build a phylogenetic tree, and more specifically when possible a dated phylogeny, in which the dates of all common ancestors are estimated. Here, we propose a new Bayesian methodology to construct dated phylogenies which is specifically designed for bacterial genomics. Unlike previous Bayesian methods aimed at building dated phylogenies, we consider that the phylogenetic relationships between the genomes have been previously evaluated using a standard phylogenetic method, which makes our methodology much faster and scalable. This two-step approach also a

SUBMITTER: Didelot X 

PROVIDER: S-EPMC6294524 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature