Subunit composition of glutamate and gamma-aminobutyric acid receptors in status epilepticus.

ABSTRACT:

Purpose

To describe the subunit composition of glutamate and gamma-aminobutyric acid (GABA) receptors in brain tissue from patients with different types of status epilepticus.

Patients and methods

The subunit composition of glutamate and GABA receptors was analyzed in: (1) surgical brain samples from three patients with refractory convulsive status epilepticus, three patients with electrical status epilepticus in sleep, and six patients with refractory epilepsy, and (2) brain autopsy samples from four controls who died without neurological disorders. Subunit expression was quantified with Western blotting and messenger ribonucleic acid (mRNA) expression was quantified with reverse polymerase chain reaction.

Results

Western blot analysis demonstrated the following patt

SUBMITTER: Loddenkemper T 

PROVIDER: S-EPMC6294571 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature