Subjective Cognitive Decline Is Associated with Greater White Matter Hyperintensity Volume.

ABSTRACT:

Background

Research in older adults with subjective cognitive decline (SCD) has mainly focused on Alzheimer's disease (AD)-related MRI markers, such as hippocampal volume. However, small vessel disease (SVD) is currently established as serious comorbidity in dementia and its preliminary stages. It is therefore important to examine SVD markers in addition to AD markers in older adults presenting with SCD.

Objective

The aim of our study was to elucidate the role of SVD markers in late middle-aged to older adults with and without SCD in addition to the commonly found role of AD markers (hippocampal volume).

Methods

67 healthy late middle-aged to older adults participated in this study (mean age 68 years); 25 participants with SCD and 42 participants without SCD. We evalu

SUBMITTER: van Rooden S 

PROVIDER: S-EPMC6294575 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature