Cerebrospinal Fluid Alzheimer's Disease Biomarkers in Cerebral Amyloid Angiopathy-Related Inflammation.

ABSTRACT:

Background

Decreased cerebrospinal fluid (CSF) amyloid-β 1-40 (Aβ40) and amyloid-β 1-42 (Aβ42) and increased total and phosphorylated tau (t-tau, p-tau) concentrations have been described in cerebral amyloid angiopathy (CAA).

Objective

Our aim was to analyze these biomarkers in patients with CAA-related inflammation (CAA-I).

Methods

We prospectively recruited nine patients with acute phase CAA-I fulfilling Chung criteria. CSF was analyzed for t-tau, p-tau, Aβ42, and Aβ40. Data were compared to controls (n = 14), patients with Alzheimer's disease (AD, n = 42), CAA (n = 10), and primary angiitis of the central nervous system (PACNS, n = 3).

Results

For the CAA-I group, statistically significant differences were: lower Aβ42 (p = 0.00053) compared to the control gr

SUBMITTER: Renard D 

PROVIDER: S-EPMC6294577 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature