Association between Peripheral Leptin and Adiponectin Levels and Cognitive Decline in Patients with Neurocognitive Disorders ≥65 Years.

ABSTRACT:

Background

There is evidence that adipokines have roles in brain functioning and cognitive decline.

Objective

Assess the role of leptin and adiponectin levels in predicting changes in neuro-cognitive disorders (NCD).

Methods

The study included 205 patients over 65 years of age presenting for a one-day hospitalization for current assessment of cognitive function. Peripheral blood leptin and adiponectin levels were measured at admission. Demographic variables, body mass index (BMI), and history of hypertension were also recorded. Cognitive function was assessed by the Mini-Mental State Examination (MMSE) at admission and at later scheduled visits over a median follow-up period of 14.5 months. Conventional univariate comparisons were made between diagnosis groups (Alzhei

SUBMITTER: Gilbert T 

PROVIDER: S-EPMC6294588 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature