Selective infarct zone imaging with intravenous acoustically activated droplets.

ABSTRACT:

Background

Microbubbles (MB) can be compressed to nanometer-sized droplets and reactivated with diagnostic ultrasound; these reactivated MB possess unique imaging characteristics.

Objective

We hypothesized that droplets formed from compressing Definity MB may be used for infarct-enhancement imaging.

Methods

Fourteen rats underwent ligation of their left anterior descending (LAD) artery, and five pigs underwent 90 minute balloon occlusions of their mid LAD. At 48 hours in rats, transthoracic ultrasound was performed at two and four minutes following 200 μL intravenous injections (IVI) of Definity droplets (DD), at which point the MI was increased from 0.5 to 1.5 to assess for a transient contrast enhancement zone (TEZ) within akinetic segments. In pigs, 1.0 mL injectio

SUBMITTER: Choudhury SA 

PROVIDER: S-EPMC6294612 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature