Quantitative assessment of the association between GRIA1 polymorphisms and migraine risk.

ABSTRACT:

Purpose

The association between GRIA1 rs548294 G>A and rs2195450 C>T polymorphisms and migraine risk has been reported in several case-control studies. However, the results of studies are inconsistent. Thus, we conducted a meta-analysis to more precisely estimate the association of the two polymorphisms with migraine risk.

Methods

Eligible studies were retrieved and screened from the online databases (EMBASE, PubMed, Web of Science, Wanfang, and Chinese National Knowledge Infrastructure). The pooled odds ratio (OR) with corresponding 95.0% confidence intervals (CIs) was assessed using random- or fixed-effects model.

Results

A total of 1233 cases and 1374 controls from four eligible studies were included. The pooled analysis showed that GRIA1 rs548294 G>A

SUBMITTER: Gao X 

PROVIDER: S-EPMC6294621 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature