Epstein-Barr virus BORF2 inhibits cellular APOBEC3B to preserve viral genome integrity.

ABSTRACT: The apolipoprotein B messenger RNA editing enzyme, catalytic polypeptide-like (APOBEC) family of single-stranded DNA (ssDNA) cytosine deaminases provides innate immunity against virus and transposon replication^1-4. A well-studied mechanism is APOBEC3G restriction of human immunodeficiency virus type 1, which is counteracted by a virus-encoded degradation mechanism^1-4. Accordingly, most work has focused on retroviruses with obligate ssDNA replication intermediates and it is unclear whether large double-stranded DNA (dsDNA) viruses may be similarly susceptible to restriction. Here, we show that the large dsDNA herpesvirus Epstein-Barr virus (EBV), which is the causative agent of infectious mononucleosis and multiple cancers⁵, utilizes a two-pronged approach t

SUBMITTER: Cheng AZ 

PROVIDER: S-EPMC6294688 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature