Pathological correlates of brain arterial calcifications.

ABSTRACT:

Background

In clinical practice, calcifications seen on computed tomographic studies within the large brain arteries are often referred to as a surrogate marker for cholesterol-mediated atherosclerosis. However, limited data exist to support the association between calcification and atherosclerosis. In this study, we examined if intracranial arterial calcifications were associated with cholesterol-mediated intracranial large artery atherosclerosis (ILAA) within the arteries of the circle of Willis in an autopsy-based sample.

Methods

We carried out a cross-sectional analysis of histopathological characteristics of brain large arteries obtained from autopsy cases. Brain large arteries were examined for evidences of calcifications, which were rated as macroscopic (coalescent) a

SUBMITTER: Shapiro SD 

PROVIDER: S-EPMC6294705 | biostudies-literature | 2019 Jan - Feb

REPOSITORIES: biostudies-literature