Metabolic comparison of one-anastomosis gastric bypass, single-anastomosis duodenal-switch, Roux-en-Y gastric bypass, and vertical sleeve gastrectomy in rat.

ABSTRACT:

Background

One-anastomosis gastric bypass (OAGB) and single-anastomosis duodenal switch (SADS) have become increasingly popular weight loss strategies. However, data directly comparing the effectiveness of these procedures with Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (SG) are limited.

Objectives

To examine the metabolic outcomes of OAGB, SADS, RYGB, and SG in a controlled rodent model.

Setting

Academic research laboratory, United States.

Methods

Surgeries were performed in diet-induced obese Long-Evans rats, and metabolic outcomes were monitored before and for 15 weeks after surgery.

Results

All bariatric procedures induced weight loss compared with sham that lasted throughout the course of the study. The highest percent fat loss

SUBMITTER: Arble DM 

PROVIDER: S-EPMC6294714 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature