Serotonin receptors and suicide, major depression, alcohol use disorder and reported early life adversity.

ABSTRACT: Serotonin neurotransmitter deficits are reported in suicide, major depressive disorder (MDD) and alcohol use disorder (AUD). To compare pathophysiology in these disorders, we mapped brain serotonin transporter (SERT), 5-HT_1A, and 5-HT_2A receptor binding throughout prefrontal cortex and in anterior cingulate cortex postmortem. Cases and controls died suddenly minimizing agonal effects and had a postmortem interval ≤24 h to avoid compromised brain integrity. Neuropathology and toxicology confirmed absence of neuropathology and psychotropic medications. For most subjects (167 of 232), a DSM-IV Axis I diagnosis was made by psychological autopsy. Autoradiography was performed in right hemisphere coronal sections at a pre-genual level. Linear model analyses included sex and

SUBMITTER: Underwood MD 

PROVIDER: S-EPMC6294796 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature