A_2A adenosine receptor functional states characterized by ¹⁹F-NMR.

ABSTRACT: The human proteome contains 826 G protein-coupled receptors (GPCR), which control a wide array of key physiological functions, making them important drug targets. GPCR functions are based on allosteric coupling from the extracellular orthosteric drug binding site across the cell membrane to intracellular binding sites for partners such as G proteins and arrestins. This signaling process is related to dynamic equilibria in conformational ensembles that can be observed by NMR in solution. A previous high-resolution NMR study of the A_2A adenosine receptor (A_2AAR) resulted in a qualitative characterization of a network of such local polymorphisms. Here, we used ¹⁹F-NMR experiments with probes at the A_2AAR intracellular surface, which provides the hig

SUBMITTER: Susac L 

PROVIDER: S-EPMC6294957 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature