Integrated microRNA and mRNA analysis in the pathogenic filamentous fungus Trichophyton rubrum.

ABSTRACT:

Background

Trichophyton rubrum (T. rubrum) is an important model organism of dermatophytes, which are the most common fungal pathogens worldwide. Despite the severity and prevalence of the infection caused by these pathogens, current therapies are not sufficient. MicroRNA (miRNA) is a class of small noncoding RNAs that are key factors in the regulation of gene expression. These miRNAs are reported to be highly conserved in different organisms and are involved in various essential cellular processes. In this study, we performed an integrated analysis of microRNA-like RNAs (milRNAs) and mRNAs between conidial and mycelial stages to investigate the roles of milRNAs in regulating the expression of target genes in T. rubrum.

Results

A total of 158 conserved milRNAs and 12 novel m

SUBMITTER: Wang L 

PROVIDER: S-EPMC6295003 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature