Analysis of the differential urinary protein profile in IgA nephropathy patients of Uygur ethnicity.

ABSTRACT:

Background

IgA nephropathy (IgAN) is one of the most common forms of idiopathic glomerular diseases and might lead to end-stage kidney disease. Accurate and non-invasive biomarkers for early diagnosis are required for early intervention and consequent therapy for IgAN patients. Because variance in the disease incidence and predisposing genes of IgAN has been detected among different ethnicities, the ethnicity factor should be considered in IgAN biomarker discovery. The differences in the protein profiles and pathological mechanisms of IgAN in patients of Uygur ethnicity need to be clearly illustrated.

Methods

In this study, we used urinary proteomics to discover candidate biomarkers of IgAN in patients of Uygur ethnicity. The urinary proteins from Uygur normal control and Uy

SUBMITTER: Guo Z 

PROVIDER: S-EPMC6295011 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature