Epigenetic modifications acetylation and deacetylation play important roles in juvenile hormone action.

ABSTRACT:

Background

Epigenetic modifications including DNA methylation and post-translational modifications of histones are known to regulate gene expression. Antagonistic activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs) mediate transcriptional reprogramming during insect development as shown in Drosophila melanogaster and other insects. Juvenile hormones (JH) play vital roles in the regulation of growth, development, metamorphosis, reproduction and other physiological processes. However, our current understanding of epigenetic regulation of JH action is still limited. Hence, we studied the role of CREB binding protein (CBP, contains HAT domain) and Trichostatin A (TSA, HDAC inhibitor) on JH action.

Results

Exposure of Tribolium castaneum cells (TcA ce

SUBMITTER: Roy A 

PROVIDER: S-EPMC6295036 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature