Effectiveness and costs of non-invasive foetal RHD genotyping in rhesus-D negative mothers: a French multicentric two-arm study of 850 women.

ABSTRACT:

Background

The determination of foetal Rhesus D (RHD) status allows appropriate use of IgRh prophylaxis by restricting its use to cases of RHD feto-maternal incompatibilities. There is a degree of uncertainty about the cost-effectiveness of foetal RHD determination, yet screening programs are being introduced into clinical practice in many countries. This paper evaluates the impact of non-invasive foetal Rhesus D (RHD) status determination on the costs of managing RHD-negative pregnant women and on the appropriate use of anti-D prophylaxis in a large sample of RHD-negative pregnant women using individual prospectively collected clinical and economic data.

Methods

A prospective two-armed trial of RHD negative pregnant women was performed in 11 French Obstetric Departments. No

SUBMITTER: Darlington M 

PROVIDER: S-EPMC6295078 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature