Associations of sex hormone-binding globulin and testosterone with genome-wide DNA methylation.

ABSTRACT:

Background

Levels of sex hormone-binding globulin (SHBG) and the androgen testosterone have been associated with risk of diseases throughout the lifecourse. Although both SHBG and testosterone have been shown to be highly heritable, only a fraction of that heritability has been explained by genetic studies. Epigenetic modifications such as DNA methylation may explain some of the missing heritability and could potentially inform biological knowledge of endocrine disease mechanisms involved in development of later life disease. Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC), we explored cross-sectional associations of SHBG, total testosterone and bioavailable testosterone in childhood (males only) and adolescence (both males and females) with genome-wide

SUBMITTER: Arathimos R 

PROVIDER: S-EPMC6295101 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature