Unified Cox model based multifactor dimensionality reduction method for gene-gene interaction analysis of the survival phenotype.

ABSTRACT:

Background

One strategy for addressing missing heritability in genome-wide association study is gene-gene interaction analysis, which, unlike a single gene approach, involves high-dimensionality. The multifactor dimensionality reduction method (MDR) has been widely applied to reduce multi-levels of genotypes into high or low risk groups. The Cox-MDR method has been proposed to detect gene-gene interactions associated with the survival phenotype by using the martingale residuals from a Cox model. However, this method requires a cross-validation procedure to find the best SNP pair among all possible pairs and the permutation procedure should be followed for the significance of gene-gene interactions. Recently, the unified model based multifactor dimensionality reduction method (UM-MD

SUBMITTER: Lee S 

PROVIDER: S-EPMC6295107 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature