Chronic kidney disease measures and the risk of abdominal aortic aneurysm.

ABSTRACT:

Background and aims

Despite its strong link to cardiovascular outcomes, the association of chronic kidney disease (CKD) with abdominal aortic aneurysm (AAA) has not been explicitly and comprehensively investigated.

Methods

In 10,724 participants in the Atherosclerosis Risk in Communities Study (aged 53-75 years during 1996-1998), we evaluated the associations of two key CKD measures - estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (ACR) - with incident AAA (AAA diagnosis in outpatient, hospitalization discharge, or death records). Additionally, we performed a cross-sectional analysis for the CKD measures and ultrasound-based abdominal aortic diameter in 4258 participants during 2011-2013.

Results

During a median follow-up of 13.9 yea

SUBMITTER: Matsushita K 

PROVIDER: S-EPMC6295219 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature