Diffusional Kurtosis along the Corticospinal Tract in Adult Normal Pressure Hydrocephalus.

ABSTRACT:

Background and purpose

Normal Pressure Hydrocephalus is a reversible form of dementia characterized by enlarged ventricles, which can deform and cause disruptions to adjacent white matter fibers. The purpose of this work was to examine how diffusion and kurtosis parameters vary along the corticospinal tract and determine where along this path microstructure is compromised in patients diagnosed with normal pressure hydrocephalus. We hypothesized that disruption of the corticospinal tract from ventricular enlargement can be measured using diffusion MR imaging and this will be quantified in periventricular regions.

Materials and methods

We developed a method to analyze diffusion parameters at discrete points along neural tracts. We then used diffusion MR imaging data from patie

SUBMITTER: Ades-Aron B 

PROVIDER: S-EPMC6295239 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature