Loss of Function of Canonical Notch Signaling Drives Head and Neck Carcinogenesis.

ABSTRACT:

Purpose

Head and neck squamous cell carcinoma (HNSCC), a common cancer worldwide, is etiologically associated with tobacco use, high alcohol consumption, and high-risk human papillomaviruses (HPV). The Notch signaling pathway, which is involved in cell differentiation decisions with differential downstream targets and effects depending on tissue type and developmental stage, has been implicated in human HNSCC. NOTCH1 is among the most frequently mutated genes in both HPV-positive and HPV-negative HNSCC. These mutations are predicted to inactivate the function of Notch. Other studies have argued the opposite-Notch signaling is increased in HNSCC.

Experimental design

To assess the role of Notch signaling in HPV-positive and HPV-negative HNSCC, we utilized genetically en

SUBMITTER: Nyman PE 

PROVIDER: S-EPMC6295262 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature