Long noncoding RNA HOTTIP expression predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation.

ABSTRACT:

Background

The long noncoding RNA HOTTIP has recently been described as a biomarker of poor prognosis in patients with hepatocellular carcinoma (HCC).

Methods

In the present study, we evaluated the clinical significance of HOTTIP expression in predicting the rate of tumor recurrence in HCC patients after liver transplantation (LT). We examined the expression pattern and single nucleotide polymorphism (SNP) genotype of HOTTIP in HCC samples from 155 patients underwent LT, and its correlation with clinical parameters and patient prognosis was analyzed. HOTTIP was suppressed using siRNA to explore the role HOTTIP plays in tumor progression.

Results

The expression level of HOTTIP in cancer tissues was higher than in adjacent noncancerous tissues. Multivariate analyses rev

SUBMITTER: Wu L 

PROVIDER: S-EPMC6295384 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature