Inhibitory effects of cycloastragenol on abdominal aortic aneurysm and its related mechanisms.

ABSTRACT:

Background and purpose

Abdominal aortic aneurysm (AAA) is a degenerative disease affecting human health, but there are no safe and effective medications for AAA therapy. Cycloastragenol (CAG), derived from Astragali Radix, has various pharmacological effects. However, whether CAG can protect against AAA remains elusive. In this study, we investigated whether CAG has an inhibitory effect on AAA and its related mechanism.

Experimental approach

The AAA mouse model was induced by incubating the abdominal aorta with elastase. CAG was administered by gavage at different doses beginning on the same day or 14 days after inducing AAA to explore its preventive or therapeutic effects respectively. The preventive effects of CAG on AAA were verified in another AAA mouse model induced by

SUBMITTER: Wang Y 

PROVIDER: S-EPMC6295405 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature